Production by Murine Macrophages Lipopolysaccharide-Induced IL-10 Surfactant Protein A Suppresses
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Legionella pneumophila suppresses interleukin-12 production by macrophages.
In vitro infection of macrophages with Legionella pneumophila induced interleukin-1alpha (IL-1alpha), IL-10, monocyte chemotactic protein 1 (MCP-1), and MCP-3 but not IL-12. The lipopolysaccharide (LPS)-induced production of IL-12 was down-regulated by infection with virulent L. pneumophila, but other cytokines were not affected. In contrast, avirulent L. pneumophila or UV-killed, virulent L. p...
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The present study was designed to investigate the inhibitory effect of 2,4 bis-[(4-ethoxyphenyl)azo] 5-(3-hydroxybenzylidene) thiazolidine-2,4-dione (TZD-OCH2CH3) on the cyclo-oxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in RAW 264.7 cells. The effects of TZD-OCH2CH3 on COX-2 and iNOS mRNA expression in LPS-activated RAW 264.7 cells ...
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The lung collectin surfactant protein A (SP-A) has both anti-inflammatory and pro-phagocytic activities. We and others have previously shown that SP-A inhibits the macrophage production of TNF-α stimulated by the gram negative bacterial component lipopolysaccharide (LPS). We propose that SP-A decreases the production of proinflammatory cytokines by alveolar macrophages via a CD14 independent me...
متن کاملComparision of the effects of Leishmania Soluble Antigen (LSA) and Lipopolysaccharide (LPS) on C57BL/6 Mice Macrophage Function
Background: Macrophages activation is the important anti-leishmania immune response. Different signals could affect macrophages development and functional activation. Objectives: In the present study, we compared the effect of Leishmania Soluble Antigen (LSA)and Lipopolysaccharide (LPS) on peritoneal macrophage responses. Appropriate activation of macrophages depends on thesignals they receive ...
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تاریخ انتشار 2001